The BIDMC Mass Spectrometry Core Facility & John Asara Laboratory

The BIDMC Mass Spectrometry Core Facility & John Asara LaboratoryThe BIDMC Mass Spectrometry Core Facility & John Asara LaboratoryThe BIDMC Mass Spectrometry Core Facility & John Asara Laboratory

The BIDMC Mass Spectrometry Core Facility & John Asara Laboratory

The BIDMC Mass Spectrometry Core Facility & John Asara LaboratoryThe BIDMC Mass Spectrometry Core Facility & John Asara LaboratoryThe BIDMC Mass Spectrometry Core Facility & John Asara Laboratory
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OUR RESEARCH

We collaborate with researchers around the world in addition to internal research efforts...

We continue to co-publish in the highest ranking scientific journals...


CLICK TO LINK TO OUR PUBMED PUBLICATIONS 


The major focus of our laboratory is the development and application of state of the art techniques in bioanalytical mass spectrometry to assess the dynamic states of the metabolome, lipidome and proteome in biological systems both in vitro and in vivo. These include cell culture perturbations as well as biological fluids and tissue sections from human specimens as well as model sytems from mouse to drosophila. By using a variety of high throughput and high resolution mass spectrometry platforms, we can profile the flux of the metabolome and lipidome as well as profile various post-translational modifications and dynamic protein complexes, in some cases from a single sample extraction. 


Interested post-doctoral candidates are always welcome to apply to our laboratory... 

Overview of Research and Core Services

Selected Presentations from the Core Director

Serial-Omics and Untargeted Fluxomics: From Tumors to Bodily Fluids to Dried Blood Spots (pdf)Download
ASMS_Serial-Omics: From Breast Tumors to Bodily Fluids to Dried Blood Spots (pdf)Download
ABRF_Asara_Lipidomics workshop (pdf)Download
Asara_Small Molecules in a Core Setting: Targeted Metabolic Flux to Untargeted Lipidomics (pdf)Download
C13 metabolomics talk_ASMS (pdf)Download
Asara_Cross-Omics Global Phosphoproteomics and Metabolomics Reveals a Connection Between Kinase Inhibition and RNA Processing in BCR-ABL Myeloma Cells_ASMS2014 (pdf)Download
JohnAsara_A Quantitative PositiveNegative Switching Method for Shotgun Lipidomics via High Resolution LC-MSMS from any Biological Source (pdf)Download
Asara_Dino_GBMSDG_Proteomics in the Cretaceous (pdf)Download
Asara_2011_Using Tandem Mass Spectrometry to Choose Appropriate Kinase Inhibitor Drugs in Cancers (pdf)Download

Interesting recent journal articles from our laboratory for download

Nature Protocols_13C15N_MetabolicFluxProtocol_2019 (pdf)Download
Asara_Lipidomics Protocol_2017 (pdf)Download
Asara_Metabolomics_NatProtocol_2012 (pdf)Download
Huang et al IsoSearch Untargeted Flux Analysis_2020_mps-03-00054 (pdf)Download
Asara_SerialOmics_BreastCancer_SciReport_2017 (pdf)Download
Asara_SciReports_P85SHP2crossspecies (pdf)Download
Yang et al_Targeted proteomics of PI3K assembly_Cancer Research_2011 (pdf)Download
Asara_equine urine_serialomics_PLoSONE_October2017 (pdf)Download
Asara_Triomics_Anal Chem_2015 (pdf)Download
Asara_13C15Nflux_Science-2013-Ben-Sahra (pdf)Download
Asara_MM_BCRABL_PNAS_2012 (pdf)Download
Asara_Phosphoproteomics_CurrProtMolBiol_2012 (pdf)Download
Asara_Science_Trex (pdf)Download
Schweitzer_Asara_Brachy_Science paper (pdf)Download
Organ_T rex_Phylogenetics_Science (pdf)Download

3-omics from a single liquid-liquid extractionfrom preciouis biospecimens

Protein-protein interaction mapping

Continued developed of 13C/15N isotopomer flux tracing in vivo and in vitro

  • Our lab is hiring!

CLS-425, 3 Blackfan Circle, Boston, Massachusetts 02115, United States

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